Topic: hippocampal tissue

Neurodegenerative diseases are the most prevalent age-related pathologies, including Alzheimer’s disease (AD). Recent studies suggest that telomere attrition, the main trigger of cellular senescence and pathological ageing may contribute to brain dysfunction and neurodegeneration. Senescent brain cells have been observed in AD brains, and studies in a transgenic mouse model of tauopathy found that the elimination of senescent cells led to an improvement in neurodegeneration and cognitive decline. In this project, we aim to unravel the relationship between brain senescence and the onset and pro

Aims: Large-scale changes in epigenetic-mediated regulation of gene expression is known to drive the development of temporal lobe epilepsy (TLE) after a precipitating brain insult. Although long non-coding RNAs (lncRNAs) are key modulators of RNA processing, their functional involvement in epilepsy pathogenesis remains largely unexplored. Here, we perform the first comprehensive profiling study of lncRNAs during epileptogenesis and assess their utility as novel drug targets. Methods: To study lncRNA dysregulation, Next Generation Sequencing was performed on hippocampal tissue collected during