Topic: histone acetylation

Huntington's disease (HD) is a genetic neurodegenerative disease that damages primarily the striatum and leads to motor, cognitive and psychiatric symptoms. The HD striatum undergoes early specific epigenetic gene reprogramming, leading to progressive impairment of striatal neuron identity and function. Notably, genes that define striatal neuron identity are progressively down-regulated due to decreased histone acetylation (e.g. H3K27 acetylation -H3K27ac-). Additionally, developmental genes show an increase in H3K27ac, leading to their derepression. Histone acetylation is strongly connected t

Posttraumatic stress disorder (PTSD) severely deteriorates the quality of life of an increasing number of people. Fortunately, the majority of trauma-exposed individuals recovers successfully and shows resilience to these negative consequences of trauma. Understanding the neural underpinnings of trauma resilience versus susceptibility might be key to improve PTSD prevention and treatment. Maladaptive, intrusive trauma memories are a core symptom of PTSD. These memories are characterized by poor contextualization, suggesting impaired hippocampal recruitment in the trauma memory trace. This may

Dementia with Lewy Bodies (DLB) is the second most common neurocognitive pathology characterized by pathogenic deposition of α-synuclein-laden Lewy bodies within vulnerable neurons, including those of the hippocampus (HC). The strongest risk factor for sporadic Alzheimer’s disease (AD), and recently demonstrated for DLB, is the ε4 allele of apolipoprotein (APOE4) that is a major lipoprotein in the central nervous system playing a leading role in maintaining lipid homeostasis. Our group recently demonstrated that the APOE4 aggravates cognitive deficits in a mouse model of prodromal DLB – corrob