Topic: human thalamus

The activity of thalamocortical neurons is largely defined by their excitatory inputs. The key determinants of excitatory afferents are the origin, complexity, and density of axon terminals. While some quantitative data are available on these aspects of glutamatergic afferents in animals, organization of excitatory inputs is unknown in the human thalamus. In this study we determined the origin, size and density of glutamatergic axon terminals in the anterior part of the human thalamus, examined their inter- and intra-nuclear heterogeneity as well and s the interindividual variability. We used

The human thalamus participates in multiple cortical and subcortical circuits and is important for the healthy brain’s function. Structural changes in the thalamus have been reported for multiple neurological and psychiatric disorders. However, most of the existent studies included small samples, covered few brain disorders, or only investigated the whole thalamus, without taking into account the heterogeneity of this structure. Here, we aimed to investigate the volumes of thalamic subregions across several common brain disorders and the healthy population in a multi-site sample. In a large mu