Topic: hyperinsulinemia

To survive in harsh environment such as food shortages in cold seasons, some animals develop a specific physiologic state—the hibernation. Recently, a hibernation-like state was successfully induced in non-hibernators such as mice. This state is induced by activation of Qrfp neurons in the preoptic area of the hypothalamus and is called Q-neuron-induced hypothermia and hypometabolism (QIH) (Takahashi et al., Nature, 2020). The mice showed hypothermia with very low systemic oxygen consumption during QIH. However, it remains unclear how the metabolism of glucose, the main energy resource, is reg

Alzheimer’s disease (AD) is the most common cause of dementia. Metabolic disorders, including prediabetes (preDM) and type two diabetes (T2D) increase the risk to suffer AD, and may contribute to dysfunctional brain insulin signaling and abnormal tau phosphorylation. Thus, we measured cortical tau phosphorylation at Ser-199, Ser-202/Thr-205, Ser-396, Ser-404, Thr-217 and Thr-231 residues in animals reproducing PreDM and T2D, alone or with AD. We analyzed the relationship between tau phosphorylation and metabolic profile, Aβ levels, microglia activation, cytokines production and cognitive impai