Topic: IGF-1

Mild traumatic brain injury (mTBI) poses a significant public health concern due to its association with psychiatric complications, including anxiety, depression, and sleep disturbances. Insulin-like growth factor 1 (IGF-1), known for its implications in acromegaly and cancer, has been linked to metabolic syndrome in patients with obstructive sleep apnea. This study aimed to investigate the relationship between IGF-1 and post-TBI sleep disorders and its predictive value for sleep disorder onset. Fifty-nine mTBI patients underwent a 1-year follow-up assessment, among whom 20 individuals aged 41

Parkinson's disease is a neurodegenerative disorder characterized by the progressive loss of dopaminergic neurons, leading to a spectrum of motor and non-motor symptoms. While motor deficits serve as the primary criteria for diagnosis, emerging evidence suggests that non-motor symptoms may also significantly contribute to the disease's progression. In this study, our aim was to investigate the potential impact of IGF-1 on the progression of emotional-like behavioral deficits in a rat model of neurotoxicity induced by 6-OHDA infusion into the dorsolateral striatum. We evaluated behavioral chang