Topic: immature neurons

Abnormal neuronal networks arising from perturbations during early brain development contribute to neurodevelopmental disorders. Mutations and deletions of human Fasciculation and Elongation Protein Zeta 1 (FEZ1) are found in schizophrenia and Jacobsen syndrome patients. However, its roles in human brain development and manifestation of clinical pathological symptoms remain unknown. Here, using human cerebral organoids (hCOs), we observed that FEZ1 expression is turned on early during brain development and is expressed in neuroprogenitor subtypes and immature neurons. Deletion of FEZ1 disrupts

Background: Adult stem cell niches are specialized forms of extracellular matrix suitable for maintaining the development of newborn neurons. The process is regulated by internal and external factors, such as enriched environment (EE). The subgranular zone (SGZ) in the hippocampus is enriched with molecules such as tenascin C (TnC). It is a regulatory glycoprotein involved in the proliferation and migration of different cell types. The aim of this study was to examine how TnC affects the distribution of different biomolecules and the number of developing cells in the adult SGZ.Methods: To dire

In the adult mammalian brain neural stem cells (NSCs) are considered rare cells restricted to two specialised niches, the subventricular zone (SVZ) and the subgranular zone. Recent findings demonstrated that in response to injury new neurons can be generated also by parenchymal astrocytes, however the prevalence, distribution, and behaviour of these ectopic NSCs remained elusive. Consequently, the extent to which the neurogenic potential of the mature brain parenchyma differs from that of conventional neurogenic niches remains to be determined. To tackle this issue, here, we reconstructed the