Immune system

…delivery strategies aimed at the immune system or the tumour and discuss trade-offs between platforms. The programme considers how manufacturing limits and combination regimens constrain feasible approaches, and how delivery decisions influence immune activation, clinical translation and production at scale.

…alterations in the immune system have been linked to the development of schizophrenia, raising

…share many similarities with the immune system, as both are intricate networks that affect, and are affected, by the body via multiple ‘modes’ of operation. Indeed, the two systems are functionally integrated, with the brain’s immune system helping to regulate synaptic plasticity and memory. At the molecular level, memory and the immune system are functionally integrated by non-coding RNAs (ncRNAs), which have recently emerged as key regulators of cellular activity throughout the phases of memory and in the adaptive immune system. Given

…has focused on the theory that the immune system plays a significant role in mediating the heterogeneity of PD and its progression. Her lab is investigating

…in regulating the peripheral immune response and explore the question of how the brain evaluates and represents the state of the immune system it regulates.

The synapse is the core component of the nervous system and synapse formation is the critical step in the assembly of neuronal circuits. The assembly and maturation of synapses requires the contribution of secreted and membrane-associated proteins, with neuronal activity playing crucial roles in regulating synaptic strength, neuronal membrane properties, and neural circuit refinement. The molecular mechanisms of synapse assembly and refinement have been so far largely examined on a gene-by-gene basis and with a perspective fully centered on neuronal cells. However, in the last years, the invol