Topic: immunogenicity

Fabian Soltermann and Brenda Watt examine mass photometry as a complementary method for measuring therapeutic-antibody aggregates and immune complexes. The programme compares automated mass photometry with SEC-MALS and sedimentation-velocity analytical ultracentrifugation, including quantification of monomers, dimers and larger aggregates. An IL-17A/anti-IL-17 antibody study illustrates heterogeneous target-related complexes and possible implications for immunogenicity. The discussion also considers how binding geometry and target valency influence complex formation and where a rapid, low-samp

This panel examines why strong immunogenicity in cancer-vaccine development does not always translate into clinical benefit. Prasun Chakraborty, Nora Disis and Timothy Spear compare delivery strategies aimed at the immune system or the tumour and discuss trade-offs between platforms. The programme considers how manufacturing limits and combination regimens constrain feasible approaches, and how delivery decisions influence immune activation, clinical translation and production at scale.