Topic: Infrared neuromodulation

Infrared (IR) neuromodulation research over the past decade has consistently shown that temperature is an important neural state variable. Several studies have described the ability to stimulate or block peripheral nerve activity with IR radiation. The promise of IR inhibition in the treatment of neurodegenerative diseases such as epilepsy underscores the importance of further elucidating its biophysical mechanism. In this study, the effects of IR neuromodulation on cortical neurons in vivo were investigated using high-density laminar recordings. The neocortex of anesthetized rats was exposed

One of the advantages of infrared neuromodulation (INM) compared to the classical electrical stimulation is that INM does not induce photoelectric artefacts in electrophysiological recordings. Another advantageous property of INM is that the propagation of light can be shaped easier than in case of electrical signals. Therefore, the stimulus can be more directional, the neuromodulation impact can be localized. In this work an infrared optrode is presented, that can be implanted into the brain tissue and performs optical stimulation and multi-site electrophysiological recording simultaneously.

Infrared neuromodulation (INM) is a safe optical method used to stimulate neuronal populations by locally changing the temperature within the brain tissue. Sleep and neural activity during sleep are highly temperature-dependent. During anesthetized in vivo measurements, the low-frequency components increase compared to vigilance. Therefore, we examined the changes in the frequency bands corresponding to delta and theta waves and sleep spindles during continuous infrared stimulation. The experimental device used for INM was a sharp-tip optrode, that holds an embedded waveguide that transmits in

This work presents a novel micro-drive system designed to facilitate long-term investigations into rodent neural activity through the combined use of infrared neuromodulation and electrophysiological recording. Our innovative approach comprises a 3D-printed micro-drive, securely attached to the rodent's skull, along with a protective head stage to ensure the integrity of the micro-drive and the attached optical electrode (optrode) during unrestricted movement of the animal. The micro-drive interface serves as a precise tool, enabling researchers the ability to exercise fine control over the pe