Topic: Insulin signalling

Central insulin resistance is a typical trait associated with premature ageing and is shown in neurological illnesses such as Alzheimer’s disease (AD) in its early stages. In this sense, the (phosphoinositide 3 kinase)/Akt pathway mediates insulin signalling in the brain, where defective insulin signalling is a risk factor for developing AD. Several lines of evidence show that integrated coordination of neuronal responses through the PI3K /Akt pathway in the brain has a significant functional impact on key events that are negatively affected in AD. Moreover, the PIK3/Akt pathway is crucial in

Aberrant insulin signalling was recently identified as a causative mechanism of Obsessive-Compulsive Disorder (OCD). Indeed, TALLYHO/JngJ mouse models of Type 2 diabetes are compulsive and anxious, with treatment with the Type 2 diabetes drug metformin generating partial rescue. Here, we aimed to establish the mechanisms behind this insulin-behavioural axis via proteomic analysis of brain and blood. Additionally, data from Genome-Wide Association studies (GWAS) of relevant disorders were compared using Ingenuity Pathway Analysis (IPA) (Qiagen). IPA analysis of proteomic results showed dysregul