Topic: intranasal delivery

Our previous study found that ectomesenchymal stem cells derived from human pluripotent stem cells (hPSC-EMSCs) exhibited higher neuroprotective potential than hUC-MSCs, as evidenced by a more significant reduction in lesion size and apoptosis in rat brains after hypoxia-ischemia (HI). Moreover, in vitro studies demonstrated that hPSC-EMSC-derived conditioned medium (CM) had neuroprotective and neurorestorative effects through the promotion of anti-apoptosis, neurite growth and neurogenesis. In this study, we discovered that hPSC-EMSCs and hUC-MSCs expressed differential secreted factors by ut

Depression is a neuropsychiatric condition affecting 5% of the population and involving loss of interest, low mood, and anhedonia. Depression has been ranked as the third cause of the burden of disease worldwide in 2008 by the World Health Organization WHO. Depression molecular etiology is complex and still not fully understood. Common limitations of gold standard small molecule drugs include poor efficacy, off target side effects and difficult druggability of many targets. In this study we report a radically different approach deploying small engineered single domain antibodies (nanobody) tar