Topic: intrinsic spiking properties

Recent studies have shown that ON-alpha sustained (ON-αs) retinal ganglion cells (RGCs) exhibit distinct distribution patterns within the mouse retina, with a notable prevalence observed in the temporal region. RGCs rely mainly on presynaptic inputs to create meaningful outputs, however the contribution of postsynaptic RGC processing is unknown. Therefore, we compared the intrinsic spiking properties of nasal and temporal RGCs in the wild-type and degenerated mouse retina. Whole-cell patch clamp experiments were performed to measure the responses of temporal and nasal ON-αs RGCs in wild-type a

In the retina, multiple processing steps contribute to the neuronal signals sent to higher visual centers. Retinal ganglion cells (RGCs) are the final output neurons in the retinal pathway; their output is thought to be mainly determined by presynaptic inputs; however, recent evidence suggests that the biophysical properties of RGCs such as the axon initial segment (AIS) also play an important part in signal modulation.Whole-cell patch-clamp experiments were performed to measure the spiking responses of ON-alpha sustained (ON-αs), OFF-alpha sustained (OFF-αs), and OFF-alpha transient (OFF-αt)