Topic: iPSC-derived brain organoids

Reduction of adult hippocampal neurogenesis is an early critical event in Alzheimer’s disease (AD), leading to progressive memory loss and cognitive decline.The nucleoporin Nup153, besides its role in nuclear transport, has been described as a key regulator of NSC plasticity through gene modulation. Here we investigated the potential role of Nup153 as target to improve neurogenesis in the 3xTg mouse model of AD in vitro and in vivo.We found that reduced Nup153 levels characterized NSCs from the 3xTg mice (AD-NSCs) and caused inefficient proliferation, migration and differentiation that were re

Glioblastoma multiforme (GBM) is a highly aggressive brain tumor that has a poor prognosis due to tumor recurrence and lack of effective treatment options. In order to address this challenge, we developed a novel 3D in vitro model of GBM that incorporates a co-culture of human iPSC-derived brain organoids with patient-derived GBM cells and its tumor microenvironment components. This system enables the investigation of mechanisms that lead to chemotherapy resistance and facilitates the detection of potential therapeutic agents for GBM. To establish this model, we genetically engineered patient