Topic: organoids

New approach methodologies can support drug safety and efficacy evaluation while improving the mechanistic understanding of human disease and therapeutic response. This workshop addresses two barriers to their wider use: awareness of available applications and confidence that their results are biologically relevant, reproducible and translatable. Pharmaceutical developers, regulators and biomedical researchers will discuss validation, standardisation and integration of NAM-based evidence into research and development. Sessions consider human-based models, organoids, tissue microenvironments, o

NIH investigators will examine gaps in human-based models for basic biomedical research, disease mechanisms and translation. The programme covers human development and evolutionary specializations, transformative experimental models, integration of laboratory and computational methods including AI, and disease applications. Talks address stem cells, organoids, tissue architecture, vascularized models, mechanistic digital twins and reproducible disease platforms. Session discussions conclude with research priorities and next steps; medical phantom demonstrations illustrate imaging validation.

The emergence of organoids, simulations and AI-based approaches raises practical questions about how neuroscience should combine human studies with animal models. This workshop examines why animal models remain necessary for some medical questions and how complementary experimental systems can support stronger conclusions. Case studies connect brain organoids and zebrafish in rare genetic disease, rodent and human neuromodulatory systems, translation from rat experiments to clinical research, and human versus non-human primate contributions to understanding decisions and movement. A concluding

Yun Xia presents macrophage–kidney assembloids that address missing immune and vascular components in stem-cell organoids. Directed differentiation, self-organization, genetic perturbation, xenotransplantation and single-cell analysis reveal immune–epithelial interactions. Macrophages from the same parental cells acquire resident phenotypes; diabetic and polycystic kidney models show context-dependent effects on inflammation, epithelial injury and disease progression. Minoru Takasato addresses kidney organoids’ missing urinary outflow by generating bladder tissue from human pluripotent cells.

Investigate cell fate and tissue morphogenesis in the Cell Science accelerator, aiming to make multicellular behaviour predictable and programmable. Develop mechanistic and quantitative research using model organisms or organoids, supported by advanced microscopy, cell and molecular engineering, and modelling expertise. Coordinate scientific projects and supervise specialists as appropriate. The annualized salary range is USD 87,450–108,250; work is primarily onsite at 615 Westlake Avenue North, Seattle, with limited remote flexibility.

Join Melanie Chan’s Renal Genomics group at the MRC Laboratory of Medical Sciences on Imperial’s Hammersmith campus. The project investigates gene-regulatory networks in kidney and urinary-tract development and how their disruption causes congenital anomalies. Establish iPSC-derived kidney and ureteric-bud organoids, perturb candidate regulatory elements using CRISPR interference, and profile effects with single-nucleus multiomics, CUT&RUN and low-input chromosome-conformation capture. Work combines experimental testing with collaboration with bioinformaticians and clinicians and offers tr

The human brain sets us apart as a species, with its size being one of its most striking features. Brain size is largely determined during development as vast numbers of neurons and supportive glia are generated. In an effort to better understand the events that determine the human brain’s cellular makeup, and its size, we use a human model system in a dish, called cerebral organoids. These 3D tissues are generated from pluripotent stem cells through neural differentiation and a supportive 3D microenvironment to generate organoids with the same tissue architecture as the early human fetal brai