Human preterm birth leads to individually heterogeneous, spatially variable cortical thickness deviations that are lasting, glial cell-mediated, and relevant for adult IQ
Melissa Thalhammer, Jakob Seidlitz, Maria di Biase, Antonia Neubauer, Aurore Menegaux, Benita Schmitz-Koep, Dennis Hedderich, Marcel Daamen, Henning Boecker, Claus Zimmer, Josef Priller, Dieter Wolke, Peter Bartmann, Christian Sorg · FENS Forum 2024
Human brain development is affected by very preterm (VP) birth. For example, cortical thickness (CT) is aberrant on average in groups of VP neonates, children, and adults. However, distinct postmortem findings of severely impacted preterm neonates, diverse behavioral outcomes of preterm survivors, and the spatially widespread nature of hypoxia-driven pathomechanisms after VP birth imply a regionally variable and individually heterogenous impact of VP birth on brain development. We hypothesized that CT follows this pattern, from birth to adulthood, mediated by the same cell types, and relevant
ePoster · Neuroscience