Topic: irisin

A growing number of studies on mouse models of Alzheimer's disease (AD) and AD patients recently focused the attention on the neuroprotective effects of irisin, a myokine released by muscles upon exercise. Based on these findings, in the present study we aimed to investigate, in a large cohort of AD patients, the levels of irisin in the cerebrospinal fluid (CSF) and plasma, and their correlations with disease biomarkers. Biological samples were obtained from patients with Alzheimer's dementia (n=82), mild cognitive impairment (n=44) and subjective memory complaint (n=20) biologically character

The preoptic area (POA) of the hypothalamus has garnered attention regarding its pivotal role in energy balance control and thermoregulation. Activation or inhibition of specific POA neurons has been shown to affect body temperature, locomotor activity and energy expenditure. To gain novel insights into this regulatory mechanism, we have conducted a comprehensive analysis of a distinct neuronal cluster within the POA that express the neuropeptide prepronociceptin (PNOC). Using chemogenetic techniques, we selectively activated PNOC(POA) neurons of mice and observed a significant reduction in br

Dementia is a prevalent and, based on severity, disabling neurocognitive disorder that primarily affects people older than 65 years of age. There is an increasingly emerging need to identify specific markers of dementia for interventions before disease progression. Irisin is a myokine produced during exercise with multiple effects on various organs, including a neuroprotective role on brain. Here, we investigated the involvement of irisin in patients with dementia biologically classified according to the Amyloid-β-Tau-Neurodegeneration classification system. Serum and cerebrospinal fluid (CSF)