Topic: kynurenic acid

The NEGR1 (neuronal growth regulator 1) gene has been associated with schizophrenia phenotype in GWAS studies and its expression has been found to be altered in the brains of patients with schizophrenia spectrum disorders. As altered profile of circulating kynurenine pathway metabolites has been linked with schizophrenia spectrum disorders as well, we aimed to find the differences in the brain and blood serum metabolite levels between wild-type mice and Negr1-deficient mice using MK-801 (dizocilpine) and a high-fat diet. The results suggest that kynurenine metabolism is strongly biased towards

Adolescence, a critical stage of development characterized by increased neuroplasticity, is marked by a significant risk for the onset of psychiatric disorders. Inflammatory events during this period may increase the risk of developing psychiatric disorders, with tryptophan metabolism playing a potential role in this process.Our goal was to investigate whether exposure to lipopolysaccharide (LPS) during adolescence impacts emotional behaviour and the inflammatory response in adult animals in a sex-specific manner. Male and female C57BL6J mice were injected at PND36 with LPS (0.1 mg/kg i.p.) or