Topic: lipid nanoparticles

Join Marité Cárdenas’s laboratory on a one-year technical employment contract, potentially extendable during the project. Purify lipoproteins, prepare lipid nanoparticles and characterize them with omics methods and single-particle profiling. Perform cell-based functional assays, including cholesterol efflux and anti-inflammatory measurements, and quantitative data analysis. The role provides advanced microscopy and biochemical training; starting PhD studies is possible if desired. Applications close on 31 October 2026, with rolling review beginning 30 September.

Bowen Li explains how ionizable lipids are designed for lipid nanoparticles that deliver messenger RNA. The seminar covers combinatorial and machine-learning-guided design, four-component reactions for rapidly producing lipid libraries, and barcoded screening in living systems to identify formulations targeting organs and cells, including lungs, T cells and tumours. It then examines applications of AI-guided nanoparticle platforms to mRNA therapeutics. Li is an Associate Professor and Canada Research Chair at the University of Toronto's Leslie Dan Faculty of Pharmacy. Online via Zoom. Thursda