Nanoparticles

This Notice of Funding Opportunity Announcement (NOFO) from the NIH Brain Research through Advancing Innovative Neurotechnologies (BRAIN) Initiative is intended to support establishment of facilities at minority-serving institutions (MSIs) and Institutional Development Award (IDeA)-eligible institutions for scaled production and distribution of brain cell type-specific access and manipulation reagents. Reagents will be initially developed in pilot resource projects for brain cell type-specific access and manipulation across vertebrate species from the BRAIN Initiative Armamentarium project. Aw

Insufficient evidence exists regarding the effect of nanoparticles, particularly liposomes loaded with a statin, on traumatic brain injury (TBI). We investigated the impact of atorvastatin-loaded PEG (polyethylene glycol) conjugated liposomes (LipoStatin) on outcomes in mice with TBI. PEGylated liposomes loaded with atorvastatin were developed as nanoparticles to specifically accumulate in the injury region and release the drug to lessen the harmful effects of TBI. TBI was induced using the Marmarou method, applying five consecutive head impacts at 12-hour intervals with a weight of 120 g for

…for the self-assembly of polyhedral nanoparticles (NPs) based on their crystal structures in non-Euclidean space. We show that the unavoidable geometrical frustration of these particle shapes, co

…simple case of spherical or rod-shaped nanoparticles binding to lipid-bilayer membrane vesicles results in a remarkably rich set of morphologies that can be reliably controlled via the particle binding energy. When the binding energy is weak relative to a