Topic: live imaging

The Vps10p-Domain (Vps10p-D) receptor family consists of Sortilin, SorLA, SorCS1, SorCS2 and SorCS3. They mediate internalization and intracellular sorting of specific cargo in various cell types, including neurons, but underlying molecular determinants are incompletely understood. Deciphering the dynamic intracellular itineraries of Vps10p-D receptors is crucial for understanding their role in physiological and cytopathological processes. However, studying their spatial and temporal dynamics by live imaging has been challenging so far, as terminal tagging with fluorophores presumably impedes

Axon diameter varies up to 100-fold between distinct neurons in the central nervous system with larger axons exhibiting faster nerve conduction velocity. Further axon diameter influences myelination and its dynamic regulation might help fine-tune the timing of signal propagation and thus neural circuit function. Despite its importance, we know surprisingly little about how axons grow to such different diameters in the living nervous system and which mechanisms underlie this diversity. To fully understand how nervous systems are built, functionally mature, and remain healthy, we need to underst