Topic: locomotor behavior

Achyrocline satureoides aqueous extract (ASAE) protective effects were evaluated on dopaminergic neurodegeneration induced by reserpine in Caenorhabditis elegans (C. elegans). Strain BY200 was cultured following standard procedure. The worms (L1 stage) were exposed to the treatments, ASAE (10 or 25 mg/ml) or no for 24 hours, followed by the induction of dopaminergic damage (reserpine, 60 µM, positive control; PC) or no (negative control; NC). Worm’s images (n=20) were captured using a fluorescence microscope and quantified using the ImageJ software. The locomotor behavior (body bends) of the w

Methamphetamine (MA) is a psychostimulant with a high potential for abuse and neurotoxic effects, primarily affecting the brain's monoamine neurotransmitter systems. Recently, its overdose or concurrent use with alcohol (EtOH) has been associated with a notable increase in hospitalizations and mortality. In this study, we examined locomotor behavior, as well as metabolic and pharmacokinetic interactions, following the co-administration of low, medium, and high doses of MA (hydrochloride salt, 1, 4, and 10 mg/kg, intraperitoneal) and EtOH (2 g/kg, 30%, v/v, intraperitoneal) in rats. Locomotion