Topic: long-term plasticity

CA3-CA1 synapses in the hippocampus are the initial locus of episodic memory. The action of acetylcholine alters cellular excitability, modifies neuronal networks, and triggers secondary signaling that directly affects long-term plasticity (LTP) (the cellular underpinning of memory). It is therefore considered a critical regulator of learning and memory in the brain. Its action via M4 metabotropic receptors in the presynaptic terminal of the CA3 neurons and M1 metabotropic receptors in the postsynaptic spines of CA1 neurons produce rich dynamics across multiple timescales. We developed a model

Biological circuits adapt their behaviour through experience and ongoing learning in a non-trivial manner. Experimental evidence shows differing neuronal population responses to familiar and novel stimuli [1, 2], indicating that neural circuits operate in distinct processing modes depending on stimulus familiarity. In layer 2/3 of mouse primary visual cortex (V1) specifically, populations of pyramidal and vasoactive-intestinal-peptide-expressing (VIP) cells show pronounced responses to novel visual stimuli (novelty responses) and weaker responses to familiar ones. Although experimental and the