Topic: lysosomal acidification

Microglia, the tissue-resident macrophages of the central nervous system, actively participate in brain development by supporting neuronal maturation and refining synaptic connections. These cells are emerging as highly metabolically flexible, able to oxidize a variety of nutrients to meet their energy demand. Accumulating evidence points towards the involvement of metabolism and differential substrates catabolism in the regulation of immune cells. Lactate, which is abundant in the brain and sustains synaptic activity, also dictates responses of peripheral immune cells. However, the physiologi

Microglia are crucial players in brain injury, orchestrating inflammatory responses, scavenging cellular debris, and promoting plasticity for functional recovery. To perform these functions, microglia undergo specific metabolic adaptations. Ex vivo evidence shows that, when subjected to glucose depletion, microglia are able to maintain their motility and surveillance, thanks to their high metabolic flexibility. However, the energetic sources sustaining their flexibility in vivo remain unclear. Ischemic stroke is characterized by a sudden drop in nutrients and oxygen supply, while extracellular