Seminar · Computational Neuroscience
Acetylcholine modulation of short-term plasticity is critical to reliable long-term plasticity in hippocampal synapses
Rohan Sharma · Suhita lab, Indian Institute of Science Education and Research Pune
Wed, Jul 28, 2021 · 17:00 UTC
CA3-CA1 synapses in the hippocampus are the initial locus of episodic memory. The action of acetylcholine alters cellular excitability, modifies neuronal networks, and triggers secondary signaling that directly affects long-term plasticity (LTP) (the cellular underpinning of memory). It is therefore considered a critical regulator of learning and memory in the brain. Its action via M4 metabotropic receptors in the presynaptic terminal of the CA3 neurons and M1 metabotropic receptors in the postsynaptic spines of CA1 neurons produce rich dynamics across multiple timescales. We developed a model