Topic: Mas receptor

The heptapeptide angiotensin (Ang 1-7: Asp-Arg-Val-Tyr-Ile-His-Pro) is one of the main endogenous components of the protective arm of the renin-angiotensin system (RAS). Acting on the Mas receptor (MasR), it exhibits vasodilator, antiproliferative, anti-inflammatory, and neuroprotective effects. To improve its enzymatic stability, water solubility, and receptor affinity, some new structural analogs of the natural peptide Ang 1-7 with conformationally constrained amino acids have been synthesized, characterized, and tested for biological activity. Solid-phase peptide synthesis—the Fmoc-strategy

The renin-angiotensin system (RAS) is a key regulator of body homeostasis and is involved in modulating brain functions. Two opposing arms are thought to constitute the RAS: the pressor arm consists of Ang II, and AT1 receptors, mediating vasoconstrictor, proliferative, and proinflammatory effects, and the AT2 receptor, which opposes the effects of the AT1R. The depressor arm includes angiotensin-converting enzyme type 2 (ACE2) and Ang-(1-7), which mediate vasodilatory, antiproliferative, anti-inflammatory, and neuroprotective effects through the Mas receptor (MasR). This study aimed to elucid