Topic: maternal high-fat diet

Maternal high-fat diet (HFD) during pregnancy and lactation induces depression-like phenotype and provokes myelin-related changes in rat offspring, which persist even to adulthood. Due to the plasticity of the developing brain, we decided to analyze whether depression-like phenotypes and myelin-related changes in the early lifetime induced by maternal HFD could be reversed by the omega-3 fatty acid-enriched diet (Ω3D). We investigated the effects of the Ω3D from the post-weaning period until adulthood (63rd day of life) in offspring on the depressive-like behavior (forced swimming test, locomo

Maternal obesity during pregnancy is a significant global health concern, impacting the metabolic, cardiovascular, and neurological health of the offspring, the latter being a research topic that has become of great interest. Our study investigates their effects on cognition, focusing on the hippocampus, a region vulnerable to prenatal insults. While maternal high-fat diet (mHFD) has been linked to cognitive deficits and hippocampal changes, its impact on synaptic transmission remains unexplored.Our focus was to understand how this adverse prenatal environment influences memory processes and w

Maternal high-fat diet (mHFD) during pregnancy leads to increased inflammation and oxidative stress, representing an important risk factor for fetal neurodevelopment. We have previously shown, in a mouse model of mHFD, sex-dimorphic negative outcomes in the adolescent offspring, disrupting hippocampal Bdnf-Nrf-2 crosstalk specifically in females. In this study, we hypothesize that sex-differences are still present during adulthood, affecting cognition and neurotransmission. Furthermore, we tested a maternal dietary supplementation with the antioxidant N-acetyl-cysteine (NAC) as a preventive st