Topic: mechanical hyperalgesia

The K/BxN serum-induced arthritis mouse model is used as a human rheumatoid arthritis (RA) model. Previous results demonstrated that after the arthritogenic K/BxN serum injections joint edema and inflammation are pronounced for 9 days, then decrease, while hyperalgesia persists. We applied manganese-enhanced magnetic resonance imaging (MEMRI) after arthritogenic K/BxN or non-arthritogenic BxN serum administration on days 9 and 21, to detect pain-related brain activity reflecting the inflammatory and non-inflammatory phases of this model. MRI scans were conducted before and 24 hours after the M

Burns of diverse etiologies pose a significant health burden, resulting in varying levels of tissue damage and pain. Despite extensive research utilizing mouse models to elucidate burn-induced pain and recovery, discrepancies across different methodologies underscore the intricate complexity of burn pain and the necessity of standardized burn injury paradigms. To address this limitation, we developed the Burn Injury by Repeated Heat Exposure (BIRHE) model. By laying the hind paw for 10-seconds to a 52°C plate for 10 or 20 repetitions we reproducibly induce distinct pain intensities. We used th

Neuropathic pain is an intractable disease which in case opioids provide inadequate analgesia. It has been previously reported that voluntary wheel running prevented persistent hyperalgesia in sciatic nerve ligation (PSNL) mice. However, the mechanism of the preventive effect of the voluntary wheel running on persistent hyperalgesia was unknown. Since the anterior cingulate cortex (ACC) has been known to play an important role in chronic pain, we investigated factors associated with the attenuated hypersensitivity on voluntary wheel running in the ACC of the PSNL mice.A partial sciatic nerve l