Topic: mechanisms of disease

The MRC fellowship combines clinical research training with a programme addressing human health, from mechanisms of disease to translational research. It supports researchers developing a clinical academic career with supervision in an eligible host department. Research can cover infection, immunity, molecular medicine, population health, neuroscience, mental health and related MRC areas. Fellows should normally start between October 2027 and January 2028. The application deadline is 13 January 2027 at 16:00 UK time.

MRC funding for academically led research using experimental interventions or challenges in humans to investigate mechanisms of disease. Projects should address an important mechanistic question and show a credible route to clinical impact. The opportunity covers all disease areas and supports established and new investigators. Purely efficacy-focused trials and untargeted observational studies do not meet this mechanistic remit. Applicants must be based at a research organisation eligible for MRC funding; international project co-leads may participate under UKRI rules. There is no fixed awar