Topic: medial perforant path

Stress during adolescence is a known risk factor for neuropsychiatric disorders later in life, but how different factors alter the susceptibility to lasting cognitive or affective impairment is only partially understood. Here, we asked whether activin, a member of the TGF-β family, has a role in this process, the rationale being that activin affects the neural underpinnings of cognitive performance and affective behavior in the adult brain. We combined a mouse model of adolescent stress (corticosterone between postnatal days 30-45) with a transgenic mouse line expressing a dominant-negative mu

Adolescence binge drinking impacts on cognition and behavior through the brain endocannabinoid system (ECS). Dietary long-chain polyunsaturated omega-3 (n-3) fatty acids increase hippocampal synaptic transmission and improve memory functions. Strikingly, alcohol (EtOH) decreases n-3 in the brain, having a negative effect on synaptic plasticity. Because adolescent binge drinking causes long-term impairment of the cannabinoid-dependent synaptic plasticity at the excitatory medial perforant path (MPP) synapses of the hippocampal dentate gyrus (Peñasco et al., 2020), we hypothesize that n-3 could