Topic: memantine

Ketamine, an open-channel blocker of the N-methyl-D-aspartate receptor (NMDAR), has been shown to have rapid and sustained antidepressant effects after a single sub-anesthetic dose. Among its two enantiomers, (S)-ketamine acts more potently at NMDARs than (R)-ketamine, and its use as an antidepressant was approved by the FDA in 2019. Given that the mechanism underlying ketamine’s sustained antidepressant action remains unclear, we investigated if (S)-ketamine has any long-term effect on NMDAR-mediated synaptic transmission. In extracellular recordings from the CA1 region of mouse hippocampal s

Loss of function mutations in genes encoding lysine methyltransferases responsible for trimethylation of histone 3 on lysine 4 (H3K4me3) are associated with a range of neurodevelopmental conditions. Intriguingly, mutations of H3K4me3-specific lysine demethylases (KDMs) are also associated with autism and intellectual disability. Mutations in KDM5B have been reported in patients with autism, intellectual disability and developmental delay. We hypothesised that a deficiency in the demethylation activity of KDM5B will lead to a dysregulated H3K4me3 epigenome, abnormal neurodevelopmental gene expr

Deficits in sensory perception characterize Huntington disease (HD), alongside motor and cognitive impairments. This study investigates altered cortical network connectivity in HD, focusing on sensory spread, where sensory stimulation provokes more extensive cortical activity in HD model mice compared to wild-type (WT) controls.In vivo, we utilized widefield, mesoscale calcium imaging in the awake, head-fixed zQ175 mouse model of HD, crossed with Thy1-GCaMP mice, expressing GCaMP in cortical pyramidal neurons. In vivo, LED flashes induced visual responses imaged through an intact-skull cranial

Neural 3D organoids from human induced pluripotent stem cells (iPSC) are a rapidly developing technology with great potential for understanding brain development and neuronal diseases. A promising parallel approach is assembling structures similar to 3D spheroids or “neurospheres” by using defined combinations of fully differentiated human iPSC-derived cells in tri-culture, including glutamatergic neurons, GABAergic neurons, and astrocytes. In this study, we chose to model Alzheimer’s Disease (AD) by incorporating allelic variants of the ApoE gene (2/2, 3/4, and 4/4) to create disease-specific

Obsessive-Compulsive Disorder (OCD) entails intrusive thoughts and repetitive behaviors fueled by anxiety, influenced by cognitive, emotional, and behavioral factors. Medication is employed to address these dynamics. Recent theories explore a potential correlation between OCD symptoms and brain attractor network states, pointing to a connection with glutamatergic activity. In our investigation, conducted over three time points with 7-week intervals, we collected a comprehensive dataset comprising resting-state and task-based fMRI signals, DTI data, and metabolic details, particularly focusing