Mental disorders

…Basic Neuroscience or Translational Mental Health Research. The National Institute of Mental Health (NIMH) seeks teams of integrative researchers working at different levels of analysis and employing novel, and creative experimental approaches to address high-risk, high-impact questions with the primary objectives of: (a) advancing basic brain and behavior research that will uncover underlying mechanisms that could provide the foundation for understanding mental disorders; (b) supporting the integ

…into treatments for brain and mental disorders. Drawing on Elusive Cures, she considers the relationship between memory and mood, robustness and fragility, modelling, standardisation and iterative changes in how researchers frame the problems they study.

Recent meta-analyses indicate that non-neurobiological treatments for mental disorders, such as psychotherapy, demonstrate variable success rates ranging from 30% to 60% [Munder et al., 2019] . However, there is no consensus on the theoretical upper limit of these treatments [Cuijpers et al., 2024]. This study aims to estimate this upper bound by examining the alignment between network control properties of emotional and whole-brain fMRI responses to visual emotional stimuli. We hypothesize that the upper limit of non-neurobiological treatments (i.e., treatments that do not monitor brain resp

Burnout Syndrome refers to a type of work and institutional stress generated in professionals who maintain a constant and direct relationship with other people, especially when this is classified as help (doctors, nurses, teachers), and its origin is based on how these individuals interpret and maintain their own professional stages in crisis situations.Currently, different institutions are experiencing an overwhelming demand for services after the COVID 19 pandemic, so we want to evaluate the work stress of the subjects who work in these institutions such as Hospitals and Universities.A prosp

Mental disorders, including depression and anxiety, are a major health concern worldwide, affecting more than 540 million people globally. Although there are treatments available to help with various symptoms, cognitive deficits, particularly impaired executive functions, are often not addressed. In this study, we aim to investigate the effectiveness of HBK-15, a multimodal compound known for its rapid antidepressant-like effect, in reducing cognitive flexibility deficits in mice.We used male Balb/c mice. To assess the effect on cognitive flexibility, we used touchscreen-based two-choice pairw

On Wednesday, October 26th, at noon ET / 6PM CET, we will host Kara Johnson, PhD, and Ludvic Zrinzo, MD PhD, for the inaugural session of our newly conceived talk series format entitled "Stimulating Brains". Kara A. Johnson, a postdoctoral fellow in Dr. Coralie de Hemptinne’s lab at the University of Florida, will present her work on “Combining imaging and neurophysiology in Parkinson’s disease”. Ludvic Zrinzo, Professor of functional neurosurgery and head of the University College London functional neurosurgery unit, will give us a glimpse at the “Person behind the science”, and give a talk o

The World Health Organization (WHO) estimates that untreated mental disorders accountfor 13% of the total global burden of disease, and by 2030, depression alone will be the leadingcause of disability around the world – outpacing heart disease, cancer, and HIV. This grim pictureis further compounded by the mental health burden delivered by the coronavirus pandemic.The lack of novel treatment options in psychiatry is restricted by a limited understanding in theneuroscience basis of mental disorders, availability of relevant biomarkers, poor predictability inanimal models, and high failure rates