Topic: Mesoscopic calcium imaging

Working memory, the process through which information is transiently maintained and manipulated over a brief period, is essential for most cognitive functions. However, the mechanisms underlying the generation and evolution of working- memory neuronal representations at the population level over long timescales remain unclear. Here, to identify these mechanisms, we trained head-fixed mice to perform an olfactory delayed-association task in which the mice made decisions depending on the sequential identity of two odours separated by a 5 s delay. Optogenetic inhibition of secondary motor neurons

Cross-modal recruitment of visual cortical areas by auditory and somatosensory stimulation have often been reported in early blind humans. However, lower resting-state functional connectivity (rsFC) between visual and somatosensory and auditory cortical areas and weaker interhemispheric rsFC have been reported in blind humans. Moreover, rsFC is more variable in blind individuals than in sighted controls. Cross-modal recruitment of visual cortical areas has also been shown in mice. Cross-modal activation involves modifications of the excitatory/inhibitory balance, rather than establishing new c

Atypical responses to sensory stimuli are considered a core aspect and early life marker of Autism Spectrum Disorders (ASD). Although recent findings performed in mouse ASD genetic models report sensory deficits, these were explored exclusively during the juvenile or adult period. Our research concentrates on neonate mice lacking the autism-associated gene Magel2. MAGEL2 is an imprinted gene highly expressed in the hypothalamus that is paternally expressed and for which paternal deletion and point mutation cause Prader-Willi and Schaaf-Yang respectively; two syndromes with a high prevalence of