Metabolic disorders

…syndromes, muscular dystrophies and metabolic disorders, alongside clinical-trial methods and treatment challenges in settings with limited resources. Each day includes a 90-minute case-based workshop and discussion with experts, complemented by a library of recorded teaching. 14–16 December, 15:00–19:00 each day; Europe/Paris (CET, UTC+01:00). Entirely online, with up to 20

Obesity and metabolic disorders are linked with neurodegenerative diseases through persistent peripheral inflammation caused by metabolic alterations, which underlies chronic neuroinflammation. Pleiotrophin (PTN) is a cytokine that regulates neuroinflammation and metabolism in different contexts. Thus, our study aimed to determine the role of PTN in the brain-periphery crosstalk in a high-fat diet (HFD)-induced obesity model. Three-month-old C57BL/6J wild-type (Ptn+/+) and Ptn genetically deficient (Ptn−/−) mice were fed with standard chow diet or HFD (60% kcal fat) for 6 months. HFD-Ptn−/− mi