Topic: metabolic flexibility

Exercise improves clinical state of patients with Parkinson’s disease (PD), while deterioration of glucose metabolism and type 2 diabetes contribute to the progression of PD. Our aim was to assess the effects of exercise on cognitive functions, physical fitness, glucose and energy metabolism as well as on the molecular composition of cerebrospinal fluid (CSF) of patients with PD. Patients (M:F 9:8) aged 61.1 ± 8.8yrs; H&Y score I-III, BMI 27.6 ± 5.4 kg.m-2, completed a 4-month supervised aerobic-strength training (3x1h weekly). Clinical state was assessed by the United-Parkinson-Disease-Ra

Microglia are crucial players in brain injury, orchestrating inflammatory responses, scavenging cellular debris, and promoting plasticity for functional recovery. To perform these functions, microglia undergo specific metabolic adaptations. Ex vivo evidence shows that, when subjected to glucose depletion, microglia are able to maintain their motility and surveillance, thanks to their high metabolic flexibility. However, the energetic sources sustaining their flexibility in vivo remain unclear. Ischemic stroke is characterized by a sudden drop in nutrients and oxygen supply, while extracellular