Topic: Methamphetamine

Methamphetamine (MA) is a psychostimulant with a high potential for abuse and neurotoxic effects, primarily affecting the brain's monoamine neurotransmitter systems. Recently, its overdose or concurrent use with alcohol (EtOH) has been associated with a notable increase in hospitalizations and mortality. In this study, we examined locomotor behavior, as well as metabolic and pharmacokinetic interactions, following the co-administration of low, medium, and high doses of MA (hydrochloride salt, 1, 4, and 10 mg/kg, intraperitoneal) and EtOH (2 g/kg, 30%, v/v, intraperitoneal) in rats. Locomotion

Numerous studies have demonstrated the correspondence between orexin transmission and reward-related behaviors. Orexin receptors are expressed in the hippocampus regions such as CA1, CA2, and CA3, as well as the DG region. The hippocampus is essential in learning and memory, and there is a correlation between reward and learning and memory processing. The dentate gyrus (DG) is the main gateway of the hippocampal formation, receives and integrates inputs from the rest of the hippocampus formation and regulates addiction-related behaviors. Methamphetamine and other psychostimulants can produce a

Methamphetamine (MA) is a highly addictive psychostimulant abused worldwide that causes long-term behavioral changes that are linked to changes in the brain. The third trimester and adolescence are critical periods of development as the body undergoes dramatic changes and becomes more sensitive to the effects of the drug. This study aimed to investigate the effect of MA exposure during the first 12 postnatal days of laboratory rats, corresponding to the human third trimester, on hippocampal neurotrophin levels in adolescence. Exposure was performed either directly (daily subcutaneous injection