Topic: microglial cells

N-Methyl-D-Aspartate receptor (NMDAR) encephalitis is a neurological disorder mediated by autoantibodies targeting the NMDAR. Patients’ autoantibodies are pathogenic, as they cause neuronal dysfunction in vitro, and molecular and behavioral changes in mouse models of cerebroventricular transfer of patients’ antibodies. Active immunization models have confirmed these effects and informed on the development of adaptive immune responses. Here we aimed to characterize the accompanying innate immune response and how this contributes to disease pathogenesis. Female C57BL/6 mice were immunized with N

INTRODUCTION: A lot of evidence demonstrates that Formyl-Peptide Receptor 2 (FPR2), fulfills various functions in the brain. Interestingly, based on agonist biased, this receptor can induce pro- and anti-inflammatory responses depending on the chemical structure of ligands. Recently, we have synthesized a new class of non-peptidic compounds that can activate.AIM: The present study aimed to determine the anti-inflammatory effect of FPR2 agonists: IG-4 in microglial cell cultures isolated from the brains of adult mice which are a human amyloid precursor protein (hAPP) knock-in mouse model of Alz

Aging is a ubiquitous biological process that results in the progressive deterioration of various organs and tissues due to the accumulation of different kind of damage throughout life. The brain is one of the most affected organs, making aging a key player in the development of neurodegenerative diseases, including Alzheimer's (AD) and Parkinson's disease (PD), the most prevalent ones.Understanding the processes occurring during aging may open up possibilities for new strategies to maintain good health throughout lifespan. Our research group has been working for years on the study of galectin

Spinal cord injury (SCI) is a trauma that results in loss of function below the site of injury. Additionally, SCI induces systemic inflammation, which is in part responsible of brain dysfunction. Currently, many therapeutic approaches have been carried out. In particular, transplantation of bulbar olfactory ensheathing cells (bOECs) has shown therapeutic effects in mice and, to a lesser extent, in humans. Given these observations, we wondered about the effect of the lesion on the quality of the transplanted therapeutic material when cells are harvested after SCI. First, the effects of SCI on b