Topic: microstructures

To date, our understanding of how the human brain retrieves, processes, and stores information remains limited. A specific challenge lies in unravelling how local plasticity mechanisms shape the transfer of information between neurons. Traditional approaches to studying local plasticity in vitro, such as patch clamp or calcium imaging, are often limited by low throughput or the ability to record only from a subset of neurons within intricate networks. In response to these challenges, we adopt a bottom-up approach to engineer low-density neuronal networks with defined architectures. Human induc