Topic: midazolam

The ventral hippocampus has emerged as a central hub for the orchestration of negative effects. We employed wireless amperometric O2 measurements in freely moving rats as a surrogate readout for changes in neuronal activity with translational value for fMRI studies in humans. From the Research Domain Criteria (RDoC) matrix, here, mainly one branch, namely the negative valence system is addressed using a modified Elevated Plus-Maze, male Wistar rats are tested under controllable (modified Elevated T-Maze, mETM with free exploration of one open and two closed arms) and uncontrollable (Open Arm C

Birth asphyxia (BA) is one of the most serious birth complications affecting infants and can result in severe disabilities including mental retardation, cerebral palsy, and epilepsy. Animal models of BA and subsequent hypoxic-ischemic encephalopathy (HIE) are important to characterize functional and behavioral correlates of injury, explore underlying mechanisms, and assess the potential of novel therapeutic strategies. Using a non-invasive, physiologically validated rat model of BA and acute neonatal seizures that mimics many features of BA and HIE in human infants we studied (i) the temporal