Topic: miniature microscope

The Miniscope Project -- an open-source collaborative effort—was created to accelerate innovation of miniature microscope technology and to increase global access to this technology. Currently, we are working on advancements ranging from optogenetic stimulation and wire-free operation to simultaneous optical and electrophysiological recording. Using these systems, we have uncovered mechanisms underlying temporal memory linking and investigated causes of cognitive deficits in temporal lobe epilepsy. Through innovation and optimization, this work aims to extend the reach of neuroscience research

The hippocampus is presumably involved in spatial navigation, the formation of long-term memories in mammals, and the construction of a cognitive map of space using a prominent feature – place cells [1] (PCs). It is unclear how PCs’ neural codes are related to memory: turnover of neural representations could be involved in learning, while codes’ stability may support long-term storage and retrieval of memories [2]. In this work, we focus on the analysis of one-photon (1P) calcium imaging data recorded from mouse CA1 during free foraging in a two-dimensional arena with the help of a miniature