Topic: mir-132

Obsessive-compulsive disorder (OCD) is a common psychiatric disorder characterized by disturbing thoughts, mental pictures (obsessions), and repetitive behaviors (compulsions). Despite the current utilization of pharmacologically selective serotonin reuptake inhibitors (SSRIs) and cognitive-behavioral therapy, persistent symptoms are reported in 40-60% of patients. Hence, we aim to analyze the levels of specific miRNAs and comprehensively evaluate the levels of serotonin, a pivotal neurotransmitter in the context of OCD. In the present study, blood serum was taken from peripheral whole blood s

Alzheimer’s disease (AD) is a devastating neurodegenerative disorder characterized by the accumulation of β-amyloid plaques and Tau-containing neurofibrillary tangles, with no effective treatment currently available. To address the complex nature of AD pathology, we investigate a "multiple drugs – multiple targets" approach leveraging miRNA-based therapeutics. miRNAs, short non-coding RNAs, offer unique potential for gene network-based therapies due to their ability to regulate multiple genes within common biological pathways. Dysregulated miR-124 and miR-132, implicated in AD pathology, prese