Topic: miRNA

Cerebral function depends on the transmission of chemical signals between neuronal elements at synapses. Over the last two decades, accumulating data have shown that this fundamental process is regulated by astrocytes. Among other functions, astrocytes participate in the clearance of ions and neurotransmitters. In addition, these glial cells release gliotransmitters to regulate synaptic functions such as basal synaptic transmission and long-term synaptic plasticity. Clearance and gliotransmission are not the only ways through which astrocytes influence neuronal communication. One interesting b

The biological potential of extracellular vesicles (EVs) arises from their ability to transport and deliver cargo within and across cells. While widely accepted as a cell-cell communication vehicle, the dynamic range of these vesicles during brain development remains largely unexplored. Knowing this, we aimed to identify novel avenues of cellular communication and unravel the contribution of EV cargo to brain development. Leveraging a multi-omics approach, we profiled the miRNA, RNA, and proteomic contents of EVs spanning embryonic to juvenile states of mouse brain development. With this appro