Topic: mitochondrial fragmentation

Cellular hallmarks of neurodegenerative diseases include loss of synapses, neuronal death, inflammation, energy homeostasis defects, oxidative stress, mitochondrial dysfunction, and aberrant proteostasis. AMP-activated kinase (AMPK) maintains energy homeostasis by responding to fluctuating ATP levels, with diverse targets ranging from changing the transcriptional program, promoting glucose uptake, inhibiting protein synthesis, inducing mitochondrial fission, mitophagy and autophagy. Evidence indicates that AMPK is hyperactivated in Alzheimer’s disease (AD), and amyloid-β (Aβ) can activate AMPK

The neural control of sleep requires that sleep need is sensed during waking and discharged during sleep. While sleep loss has widespread consequences in the whole body and brain, perhaps the only realistic opportunity for separating causation from correlation exists in specialist neurons with active roles in sleep. To obtain an unbiased view of molecular changes in the brain underlying these processes, we characterized the transcriptomes of single sleep-control cells isolated from rested and sleep-deprived flies. Transcripts upregulated after sleep deprivation, in sleep-control neurons projec