Topic: mitochondrial gene expression

In the developing hippocampus, once generated, the pyramidal neurons migrate along radial glia processes to form the complex CA regions. Therefore, it is critical to understand the mechanisms controlling neuronal motility, leading to coordinated neuronal function. Doublecortin (DCX) shows mutations in human lissencephaly and heterotopia associated with epilepsy and intellectual disability. In the Dcx mouse mutant, the CA3 pyramidal region in the hippocampus forms an abnormal double layer, typical of heterotopia. Consequently, the mutant mouse presents an increased susceptibility to epilepsy. S

Amyloid beta1-42(Aβ1-42) peptide, a major pathological component of Alzheimer's disease(AD), is known to locate and accumulate in the mitochondria.Research has demonstrated that nuclear transcription factors(nTF) play a direct or indirect role in the transcriptional regulation of mitochondria, which lose function in the early stages of neurodegenerative diseases.Based on this information, our study investigates the interactions between Aβ and nTFs in mitochondria.In this study, the interaction of 48 nTFs with Aβ was examined using a nTF-interaction kit. Mitochondrial lysate isolations were per