Topic: monocytes

ePoster: 2 ePosters

Meninges as an overlooked pharmacological target for globoid cell leukodystrophy

Alessia Amenta, Zulkifal Malik, Giulia Pruonto, Alessandra Ricca, Federica Cascino, Sissi Dolci, Francesca Ciarpella, Marco Riva, Ilaria Decimo, Angela Gritti, Francesco Bifari · FENS Forum 2024

Globoid cell Leukodystrophy Disease (GLD) is a neurodegenerative life-threatening disease caused by genetic defects in the lysosomal enzyme galactosylceramidase (GALC). There is no cure for GLD. Treatment options are still very poor. Here, we consider GLD pathogenesis from an entirely new angle, changing the focus from the neurons and oligodendrocytes to the non-parenchymal brain cells. Meninges host neural stem/precursor cells with neuronal differentiation potential and are emerging as injury-induced site in many neurodegenerative diseases. To study the involvement of meninges in GLD pathogen

ePoster · Neuroscience

Temporal analysis of the infiltration dynamics of pro-inflammatory cytokine-producing innate and adaptive immune cells following experimental traumatic brain injury in mice

Sahil Threja, Nathan Strogulski, Janeen Laabei, Béré Diallo, Carly Douglas, Kingston Mills, David Loane · FENS Forum 2024

Traumatic brain injury (TBI) is the leading cause of death and disability in young adults. A key factor in the aftermath of TBI is the response to pro-inflammatory cytokines such as interleukin(IL)-1β (IL-1β), tumor necrosis factor (TNF-α), IL-6, IL-17, and interferon-γ (IFNγ). This preclinical study examined key cytokine-producing cells post-TBI in mice.Adult C57BL/6J male mice underwent controlled cortical impact or sham surgery. Mice were euthanized, and brains harvested acutely at 3 hours (h), 6h, 12h, 24h post-injury, or subacutely at 3, 10, and 28 days post-injury (DPI). Mononuclear cell

ePoster · Neuroscience