Topic: morpho-electric properties

A central question in neuroscience is how the structure of brain circuits determines their activity and function. To explore this systematically, we developed a 230,000-neuron model of mouse primary visual cortex (area V1). The model integrates a broad array of experimental data:Distribution and morpho-electric properties of different neuron types in V1.

Neurons rely on the interplay between dendritic morphology and ion channels to transform synaptic inputs into a sequence of somatic spikes. Detailed biophysical models with active dendrites have been instrumental for exploring this interaction. However, such models can be challenging to understand and validate due to the large number of parameters involved. In this work, we introduce DendroTweaks — a framework designed to illuminate how morpho-electric properties map to dendritic events, and how these dendritic events shape neuronal output. Through its graphical interface, users can access the