Topic: motor dysfunction

After stroke, one of the most critical problems for recovering patients is motor dysfunction in the limb contralateral to the affected hemisphere. Several mechanisms may contribute to the recovery of motor function after stroke. One is the recovery of neural pathways within the affected hemisphere. The contribution of the ipsilateral hemisphere is also widely discussed as it may be entirely responsible for motor recovery. The lateralized readiness potential (LRP) is one of the markers of interhemispheric balance during motor preparation. It is a fast negative deflection approximately 200 ms be

Vaccinia-related kinase 1 (VRK1) is a predominantly nuclear serine/threonine kinase implicated in nucleus disassembly and reassembly, cell cycle, and transcription regulation. VRK1 mutations in humans have been linked to several neurodegenerative diseases, including spinal muscular atrophy associated with microcephaly and impaired cognitive and motor function. Thus, it has been identified as potentially involved in the maintenance and development of the nervous system. However, precise pathophysiological mechanisms and VRK1 involvement in cognitive and motor dysfunction progression have yet to

Gut microbiota perturbation and motor dysfunction have been reported in steatosis patients. Rats with mild liver damage (MLD) also show motor dysfunction mediated by neuroinflammation and altered GABAergic neurotransmission in the cerebellum. The extracellular vesicles from mesenchymal stem cells (MSC-EVs) have emerged as a promising therapeutic proxy whose molecular basis rely partly upon TGFbeta action. Therefore, this study aimed to assess if MSC-EVs improve motor dysfunction in rats with MLD and analyze underlying mechanisms, including the role of EVs, TGFbeta, neuroinflammation, and gut m