Topic: motor function recovery

Stroke is a leading cause of adult disability and the third leading cause of death. Despite expanding reperfusion treatment indications, a significant proportion of patients (54.5%) experience poor outcomes despite successful recanalization, emphasizing the need for a clinically relevant preclinical stroke model. In response, we developed a novel mouse model involving photothrombotic (PT) occlusion and light-induced recanalization of the distal branch of the middle cerebral artery (MCA), closely mimicking ischemic progression in clinical settings.The stable occlusion of the MCA's distal branch

Spinal cord injury (SCI) results from direct damage to the spinal cord, devastating patients’ quality of life and emotional and economic stability. Unfortunately, fully effective therapeutic strategies have yet to be developed to treat this disease, affecting millions worldwide. Apoptosis and autophagy are critical cell death signaling pathways after SCI that should be targeted for early therapeutic interventions to mitigate their adverse effects and promote functional recovery. Tibolone (TIB) is a selective tissue estrogen activity regulator (STEAR) with neuroprotective properties demonstrate