Topic: multiunit activity

In order to investigate the involvement of primary visual cortex (V1) in working memory (WM), parallel, multisite recordings of multiunit activity were obtained from monkey V1 while the animals performed a delayed match-to-sample (DMS) task. During the delay period, V1 population firing rate vectors maintained a lingering trace of the sample stimulus that could be reactivated by intervening impulse stimuli that enhanced neuronal firing. This fading trace of the sample did not require active engagement of the monkeys in the DMS task and was also observed in a WM-independent passive viewing task

Infrared neuromodulation (INM) is a safe optical method used to stimulate neuronal populations by locally changing the temperature within the brain tissue. Sleep and neural activity during sleep are highly temperature-dependent. During anesthetized in vivo measurements, the low-frequency components increase compared to vigilance. Therefore, we examined the changes in the frequency bands corresponding to delta and theta waves and sleep spindles during continuous infrared stimulation. The experimental device used for INM was a sharp-tip optrode, that holds an embedded waveguide that transmits in

Sleep quantity and quality change dramatically across the lifespan of altricial mammals born with immature brains such as humans and rodents (Logan 2019, Cirelli 2020, Blumberg 2005, Blumberg 2014). Despite a crucial role for healthy development, we still know quite little about developmental sleep – especially when it comes to architecture and oscillatory dynamics, or to the emergence of global inter-regional brain cross-communication. Current methods to analyse immature sleep fail to provide the resolution needed to characterise its longitudinal microstructure. We designed light-weighted chr

Thoracic complete Spinal Cord Injury (Th-SCI) produces physiological changes in the hindlimb somatosensory cortex (S1HL), which we have characterized as neuronal network hyperexcitability. Moreover, we have found a decreased GAD67 labeling intensity in the infragranular layers of S1HL in chronic Th-SCI. However, it is unknown how decreased labeling of GAD67 could be related to altered inhibitory function of GABAergic interneurons across cortical layers after SCI. The present work has two aims: characterize the physiological effect of a chronic Th-SCI over the different GABAergic neuronal popul

Fragile X syndrome (FXS), is the most common monogenetic cause of mental impairment and autistic traits. Symptoms in people with FXS include auditory hypersensitivity and communication problem, which is recapitulated in the FXS mouse model. Previous studies in FXS mice showed only moderate increased neural activity levels in different parts of the ascending auditory pathways in response to simple tones. Here we characterized whether complex sounds with a behavioural relevance, such as vocalizations, evoke neural activity patterns that differ between FXS KO and WT mice. We used playback of low-