Topic: myelin integrity

Duchenne muscular dystrophy (DMD) is an X-linked neuromuscular disease characterized by the absence of the cytoskeletal protein dystrophin (Dp427). Short isoforms, such as Dp116 in myelinating Schwann cells (SCs), exist in specific cell types. In SCs, Dp116 binds to the dystrophin-associated glycoprotein complex (DGC), which crucially contributes to myelin integrity and fiber conduction properties. Our prior research on the sciatic nerve (SN) of wild-type and mdx mice, a DMD animal model lacking Dp427, revealed a significant decrease in all myelin protein levels, indicating compromised myelin

Multiple sclerosis (MS) is a devastating demyelinating disease of the central nervous system (CNS), characterised by white matter lesions, inflammation, and axonal degeneration.Pituitary adenylate cyclase-activating polypeptide (PACAP) and vasoactive intestinal peptide (VIP) are endogenous neuropeptides whose signalling is mediated by three G-protein coupled receptors: PAC1, VPAC1 and VPAC2. While these neuropeptides are known for their neuroprotective and anti-inflammatory activities in the CNS, their role in preventing demyelination, neuronal degeneration and neuroinflammation is unclear. Th