Topic: Ndr2

Nuclear Dbf2-related protein (Ndr2) is a serine/threonine kinase in the subgroup of the AGC family kinases and a core member of the Hippo signaling. Ndr2 plays a key role in the differentiation and maturation of neurons, regulating dendritic and axonal growth through integrin receptors. Further work from our lab has demonstrated that the deletion of Ndr2 kinase can improve spatial memory in old mice (see presentation by Miguel del Angel). Moreover, analysis of the hippocampal proteome revealed a differential expression of GAP43 protein in aged Ndr2 KO mice compared to wild type (WT) mice. Whil

The serine-threonine kinase Ndr2 controls axonal and dendritic growth in vertebrates and invertebrates. Further work from our group has shown that Ndr2 KO mice display deficits in synapse development, and plasticity, that lead to spatial memory impairment. Moreover, the Ndr family of kinases have recently been implicated in the regulation of autophagy, which is essential for memory formation and cognitive function during ageing. Nonetheless, the question of whether Ndr2 is involved in age-related autophagy dysregulation and the cognitive decline associated with it remained. In the current stud